Big fan of QC, that one and Starslip Crisis (www.starslip.com) are my two favorites.

Well...since I'm a Console and Pen and Paper RPG Player, Penny Arcade and Order of the Stick are my two favorite Web Comics. Anyone knows about other, good Pen and Paper "based" Webcomics?

Personally, I don't follow a lot of online comics but the one I've been coming back to the most are the CtrlAltDel-Online ( http://www.cad-comic.com )

Least I Could Do is genius
Penny Arcade is fantastic

I loved Scary Go Round and currently enjoy its successor Bad Machinery:
http://scarygoround.com

I also like Gordon McAlpin's Multiplex: http://multiplexcomic.com/index.php

Favorite web comic used to be VG Cats. Quality really declined at one point, as well as the update frequency. I liked Fanboys-Online for a while too, but same thing happened with that.
I think at the moment, my favorite is the simple pleasure that is Buttersafe. I can't describe exactly why I find some of their stupid jokes to be the funniest things I've ever read.

My top 3 are:

1. XKCD
2. The Black Cat's Batman and Sons Webcomic (http://the-dark-cat.livejournal.com/)
3. Order of the Stick (http://www.giantitp.com/)

Prefere Freak Angels
Otherwise Calvin and Hobbes

Perry Bible Fellowship has to be the best thing out there Return to sender was good too, but it was never finished

My friend draws a webcomic "C'est La Cie" at clv-comic.com
Y'all should check it out

I like Menage a 3 a lot. I just love Gisele Lagace (the artist/creator).
The comic is really funny, too.

VGCats.. that guys doesn't update very often.. but it's good..
PVP is cool..
Something Positive has a section making fun of comics now.. love it!
Penny Arcade.. yeah I took my Avatar from them.. they have a cat.. I have a cat.. they can draw.. I suck.. it works!

XKCD.. nerd stuff..

Mine are the same as some of the others. The three I always have to read are, in order of preference.

1.)Dominic Deegan-oracle for hire
2.)Looking for Group (lfg)
3.)Least I could Do (licd)